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Teemo Bruiser what? O_o</td></tr></table>
My bruiser build : BOTRK, Frozen Mallet, Insert defensive item here, Wits, and then situational depending on the enemy make up.
My mix build uses : Hybrid pen runes, Botrk, Liandrias, malady or wits, defensive item, more AP or AD depending on team weakness, leaning towards more AP. Kinda quirky since your mixing dmg types, but I focus on keeping multiple sources of HP shred and in team fights wittle down Bruisers with BOTRK + Liandrias poke from Q.
It's quirky but works for me.